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Professor Shane Crotty, Ph.D. explains recent coronavirus mutations and how they might impact COVID 19 vaccines and transmission. COVID-19 research of Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science: https://science.sciencemag.org/content/early/2021/01/05/science.abf4063.full

Prof. Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Prof. Crotty also has an academic appointment with the University of California San Diago. See his full bio here: https://www.lji.org/labs/crotty/#overview
Prof. Crotty on Twitter: https://twitter.com/profshanecrotty

Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com

TOPICS DISCUSSED IN THIS VIDEO INCLUDE:

0:00 Intro
0:08 SARS-CoV-2 / COVID 19 mutations (UK variant etc.) and implications for COVID-19 vaccines
10:58 How to test if coronavirus variants can escape immunity
12:28 How have mutations made this virus more transmissible?
17:44 Could mutations make vaccines less than 50% effective?
24:15 Possible changes to vaccine schedules (one dose, half dose)?
35:34 Could alternate COVID-19 vaccine schedule make mutations more likely?
38:29 What is next for Prof. Crotty and his team?

(This video was recorded on January 5, 2021)

PREVIOUS DISCUSSION WITH PROF. CROTTY (Dec 16, 2020):

REFERENCES:

Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn (Science) | https://www.sciencemag.org/news/2021/01/viral-mutations-may-cause-another-very-very-bad-covid-19-wave-scientists-warn

Vaccine Tracker (Bloomberg) | https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/

FDA Statement on Following the Auth. Dosing Schedules for COVID-19 Vaccines | https://www.fda.gov/news-events/press-announcements/fda-statement-following-authorized-dosing-schedules-covid-19-vaccines

S-variant SARS-CoV-2 is assoc. with sig. higher viral loads in samples tested by ThermoFisher TaqPath RT-QPCR (MedRxiv) | https://www.medrxiv.org/content/10.1101/2020.12.24.20248834v1.full-text

Human Leukocyte Antigen (HLA) System | https://www.merckmanuals.com/professional/immunology-allergic-disorders/biology-of-the-immune-system/human-leukocyte-antigen-hla-system

UK reports new variant, termed VUI 202012/01 (GISAID) https://www.gisaid.org/references/gisaid-in-the-news/uk-reports-new-variant-termed-vui-20201201/

Covid-19 in South Africa: Scientists seek to understand new variant (BBC) | https://www.bbc.com/news/world-africa-55531838

Mutation Allows Coronavirus to Infect More Cells. Scientists Urge Caution (NY Times) | https://www.nytimes.com/2020/06/12/science/coronavirus-mutation-genetics-spike.html

The UK is delaying second vaccine shots and it’s proving controversial (CNBC) https://www.cnbc.com/2021/01/05/the-uk-is-delaying-second-pfizer/biontech-shot-heres-what-we-know.html

The receptor binding domain of the SARS-CoV-2 (News Medical Life Sciences) | https://www.news-medical.net/news/20200608/The-receptor-binding-domain-of-the-SARS-CoV-2.aspx

NY Times article highlighting Prof. Shane Crotty’s research: https://www.nytimes.com/2020/11/17/health/coronavirus-immunity.html

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